Researchers are studying these markers to earn how new treatments work.
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Even while on hemophilia A treatment
Breakthrough Bleeds can Still Happen
What role do coagulation markers, like thrombin generation, play in bleed protection?
Learn more
  David, an adult man living with hemophilia A, rides his bicycle.
David, an adult man living with hemophilia A, rides his bicycle.
Strong, Stable Clots Rely on Thrombin
Thrombin helps form fibrin, a protein that acts like a mesh to hold a clot together.
image of a weaker blood clot with lower fibrin activity causing weak fibrin structure   image of a strong, stable blood clot with higher fibrin activity causing strong fibrin structure
When the body doesn’t make enough thrombin, bleeding may occur more frequently or severelya
aIn a study that evaluated 106 people with rare inherited bleeding disorders across 6 Dutch hemophilia treatment centers, insufficient thrombin generation was associated with more severe bleeding.
LEARN MORE ABOUT BLEED PROTECTION
  What is thrombin, and why is it important?
  What are the factors that may contribute to bleeds, even on prophylaxis?
  Resources to help you talk with your care team about your bleed protection.
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