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width: 670px;"> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="border-bottom: 1px solid #ffffff;"> <tr> <td valign="top" style="padding-bottom: 10px; padding-top: 10px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td class="email-gutter-15" style="padding-left: 15px; padding-right: 15px;"> <table cellpadding="0" cellspacing="0" border="0" align="left" width="100%"> <tr> <td align="left" valign="top"> <!-- Preheader text --> <div style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px;">Researchers are studying these markers to earn how new treatments work.</div> <!-- Preheader filler spaces --> <div style="display: none; max-height: 0; max-width: 0; width: 0; visibility: hidden; overflow: hidden; font-size: 1px; line-height: 0; mso-hide: all;">  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ </div> </td> <td align="right" valign="top" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; width: 100px;"><a href="#" target="_blank" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">View online</a></td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #0C0B0D; width: 670px;"> <tr> <td align="center" class="email-gutter mpt-36" style="padding-bottom: 24px; padding-left: 30px; padding-right: 30px; padding-top: 24px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" valign="middle"><a href="https://www.speakyourhemtruth.com/?tc=em_69thx3c&cc=5006&utm_medium=email&utm_source=h4h&utm_campaign=speak_your_hem_truth&utm_content=disease_information_us26hrbd00106" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;"><img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/logo-speakyourhemtruth.png" width="215" height="64" border="0" alt="SpeakYourHemTruth Logo" class="img-responsive" style="display: block; max-width: 280px;"></a></td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #0C0B0D; width: 670px;"> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <th align="center" valign="top" class="mobile-hide col-20" style="width: 20px;"> </th> <th align="center" valign="top" class="responsive-th col-360" style="font-weight: normal; width: 360px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="email-gutter-mobile-only" style="padding-left: 0; padding-right: 0;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center mfs-14 mlh-18 mpt-12" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 22px; padding-bottom: 12px; padding-top: 40px; text-transform: uppercase;">Even while on hemophilia A treatment</td> </tr> <tr> <td align="left" class="text-center mfs-28 mlh-30" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 42px; font-weight: bold; line-height: 44px; padding-bottom: 20px; text-transform: uppercase;">Breakthrough Bleeds can Still Happen</td> </tr> <tr> <td align="left" class="text-center mfs-15 mlh-20 mpb-20" style="color: #C2C2C2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 24px; padding-bottom: 28px;">What role do coagulation markers, like thrombin generation, play in bleed protection?</td> </tr> <tr> <td align="left" class="text-center mpb-32"> <a href="https://www.speakyourhemtruth.com/bleeds-still-happen.html?tc=em_69thx3c&cc=5006&utm_medium=email&utm_source=h4h&utm_campaign=speak_your_hem_truth&utm_content=disease_information_us26hrbd00106" class="button-padding-mobile-40" target="_blank" style="background-color: #9E2842; border-radius: 44px; color: #ffffff; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 15px; font-weight: normal; line-height: 20px; mso-padding-alt: 0; padding-bottom: 14px; padding-left: 30px; padding-right: 30px; padding-top: 14px; text-decoration: none; text-underline-color: #9E2842;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Learn more<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> </table> </td> </tr> </table> </th> <th align="center" valign="top" class="mobile-hide col-10" style="width: 10px;"> </th> <th align="center" valign="top" class="responsive-th col-280" style="font-weight: normal; width: 280px;"> <img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/main-image-desktop.jpg" width="280" height="420" alt="David, an adult man living with hemophilia A, rides his bicycle." class="mobile-hide" style="display: block;"> <!--[if !mso]><!--> <div class="mobile-only-content" style="display: none; max-height: 0; max-width: 0; visibility: hidden; width: 0;"> <img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/main-image-mobile.jpg" width="750" height="480" alt="David, an adult man living with hemophilia A, rides his bicycle." class="img-responsive" style="display: block; max-width: 750px;"> </div> <!--<![endif]--> </th> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter-60" style="padding-bottom: 56px; padding-left: 60px; padding-right: 60px; padding-top: 56px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="mfs-28 mlh-30 mpb-12" style="color: #252525; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 40px; font-weight: bold; line-height: 42px; padding-bottom: 20px; text-transform: uppercase;">Strong, Stable Clots Rely on Thrombin</td> </tr> <tr> <td align="center" class="mfs-14 mlh-20 mpb-28" style="color: #252525; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 24px; padding-bottom: 32px;">Thrombin helps form fibrin, a protein that acts like a mesh to hold a clot together.</td> </tr> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <th align="center" valign="top" class="responsive-th" style="font-weight: normal;"><img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/thrombin-graphic-01.png" width="260" height="310" alt="image of a weaker blood clot with lower fibrin activity causing weak fibrin structure" style="display: block;"></th> <th align="center" valign="top" height="20" class="col-10 responsive-th" style="font-weight: normal; height: 20px; width: 10px;"> </th> <th align="center" valign="top" class="responsive-th" style="font-weight: normal;"><img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/thrombin-graphic-02.png" width="260" height="310" alt="image of a strong, stable blood clot with higher fibrin activity causing strong fibrin structure" style="display: block;"></th> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #9E2842; width: 670px;"> <tr> <td align="center" class="email-gutter-40 mpt-48 mpb-48" style="padding-bottom: 56px; padding-left: 40px; padding-right: 40px; padding-top: 56px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="mfs-20 mlh-24" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 28px; font-weight: bold; line-height: 32px; padding-bottom: 20px;"><span style="text-transform: uppercase;">When the body doesn’t make enough thrombin, bleeding may occur more frequently or severely</span><sup style="font-size: 60%; line-height: 1;">a</sup></td> </tr> <tr> <td align="center" class="email-gutter-desktop-only-40" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 14px; padding-left: 40px; padding-right: 40px;"><sup style="font-size: 70%; line-height: 1;">a</sup>In a study that evaluated 106 people with rare inherited bleeding disorders across 6 Dutch hemophilia treatment centers, insufficient thrombin generation was associated with more severe bleeding.</td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #0F172A; width: 670px;"> <tr> <td align="center" class="email-gutter-80" style="padding-bottom: 56px; padding-left: 80px; padding-right: 80px; padding-top: 56px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="mfs-26 mlh-30" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 40px; font-weight: bold; line-height: 44px; padding-bottom: 28px;">LEARN MORE ABOUT BLEED PROTECTION</td> </tr> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" valign="middle" width="40" style="padding-bottom: 16px; width: 40px;"><img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/icon-checkmark.png" width="30" height="28" alt style="display: block;"></td> <td width="12" style="width: 12px;" class="mobile-hide"> </td> <td align="left" valign="middle" style="color: #C2C2C2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 24px; padding-bottom: 16px;" class="mfs-15 mlh-21">What is thrombin, and why is it important?</td> </tr> <tr> <td align="left" valign="middle" width="40" style="padding-bottom: 16px; width: 40px;"><img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/icon-checkmark.png" width="30" height="28" alt style="display: block;"></td> <td width="12" style="width: 12px;" class="mobile-hide"> </td> <td align="left" valign="middle" style="color: #C2C2C2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 24px; padding-bottom: 16px;" class="mfs-15 mlh-21">What are the factors that may contribute to bleeds, even on prophylaxis?</td> </tr> <tr> <td align="left" valign="middle" width="40" style="padding-bottom: 16px; width: 40px;"><img src="https://emails.hemo.novo.cglife.dev/emails/mim8-patient-bleeds-still-happen-h4h-july-2026/images/icon-checkmark.png" width="30" height="28" alt style="display: block;"></td> <td width="12" style="width: 12px;" class="mobile-hide"> </td> <td align="left" valign="middle" style="color: #C2C2C2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 24px; padding-bottom: 16px;" class="mfs-15 mlh-21">Resources to help you talk with your care team about your bleed protection.</td> </tr> </table> </td> </tr> <tr> <td align="center" style="padding-top: 20px;"> <a href="https://www.speakyourhemtruth.com/bleeds-still-happen.html?tc=em_69thx3c&cc=5006&utm_medium=email&utm_source=h4h&utm_campaign=speak_your_hem_truth&utm_content=disease_information_us26hrbd00106" target="_blank" style="background-color: #9E2842; border-radius: 44px; color: #ffffff; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 15px; font-weight: normal; line-height: 20px; mso-padding-alt: 0; padding-bottom: 14px; padding-left: 25px; padding-right: 25px; padding-top: 14px; text-decoration: none; text-underline-color: #9E2842;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Visit SpeakYourHemTruth.com<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #9E2842; 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